Alternative splicing of CLK1 in the THP1 cell line

Eukaryotes have the ability to alternatively splice RNA transcripts, which increases the number of proteins that a gene can code for. CLK1 play an important role in the regulation of alternative splicing. When THP1 cells were treated with the gymnema, exon4 of CLK1 was spliced out less often than in untreated cells. The exclusion of exon4 may cause the resulting protein to lose normal function. Cells treated with gymnema are probably more efficient in producing the complete CLK1.